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25HC-integrin-FAK amplifies proinflammatory response To examine whether extracellular 25HC can trigger proinflammatory response in mice, we administered (via intraperitoneal route) 25HC to C25H KO mice, as they do not produce any 25HC and the observed response will be entirely due to exogenously added 25HC

To address the issue they performed transfusion experiments with dogs where they connected the pancreatic vein of a donor dog to the jugular vein of a recipient dog and then injected secretin extracts

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