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Together, these findings highlight a distinct metabolic signature in ME/CFS, where energy production pathways may fail to respond efficiently to physical exertion, potentially driving exacerbation of symptoms seen in PEM

Sleeve gastrectomy removes the gastric fundus, which reduces lower oesophageal sphincter pressure, and creates a narrow stomach tube that increases intragastric pressure both of which promote acid reflux

Pathway inhibitor studies using specific kinase blockers confirm signalling cascade hierarchy and cross-talk mechanisms

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With a higher and more balanced metabolism, your body will convert food into energy and help to burn calories faster