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The large concentration difference between GSH and GSSG creates a dynamic-range challenge, requiring calibration and dilution procedures that maintain GSSG sensitivity without GSH saturation or carryover
2 agonist treatment (five studies with clonidine, one with lofexidine) was more effective than placebo and more likely to result in the completion of treatment, withdrawal signs and symptoms occurred and resolved earlier than methadone, and treatment duration was shorter
Participants were excluded if they had significant medical histories, abnormal lab results, or conditions affecting alcohol metabolism or absorption of the investigational product
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