They discovered that: NNMT is found in fat cells and other tissues that regulate metabolic pathways and fat storage
Its even more vital for pregnant or lactating women who are vegetarian/vegan to consume enough B12, as infants are at higher risk for B12 deficiency (7)
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It declines with age, and lower NAD+ is associated with slower metabolism and the changes we lump together as getting older. NNMT, meanwhile, consumes the raw materials your body uses to make NAD+ and in fat tissue, NNMT is often overexpressed, which can drag NAD+ down right where you least want a sluggish metabolism