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Methods Cell culture HEK293 cells (FreeStyle 293, Thermo Fisher Scientific, #R79007), adapted to serum-free suspension culture, were used for EV production

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

Selective P2X3 antagonist Eliapixant (BAY 1817080): ATP-dependent P2X3 receptors play a fundamental role in nerve fiber sensitization and pathological pain pathways

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Every kid bounces back a little differently, but recovery generally follows these key steps: The First 48 Hours: Rest (But Not Too Much!) Concussion recovery starts with rest and careful monitoring, but the old advice of total isolation in a dark room has changed

Carnitine also transports toxins out of the mitochondriathe cellular powerhouses that produce energy