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Following phagocytosis by activated macrophages, disulfide bonds in nanomedicine are broken in the presence of reducing agents such as glutathione (r-glutamyl cysteingl + glycine

RAW264.7 macrophages exposed to 50 g/mL oxLDL for 24 h displayed substantial intracellular lipid droplet accumulation and noticeable foam cell formation, as confirmed by Oil Red O (ORO) staining of the lipid droplets (Fig