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Cancer 117 (4), 563571

Nicholls SJ, Tofe S, le Roux CW, DAlessio DA, Wiese RJ, Pavo I, Brown K, Weerakkody GJ, Zeytinoglu M, Romera IC

Jujic A, Atabaki-Pasdar N, Nilsson PM, Almgren P, Hakaste L, Tuomi T, Berglund LM, Franks PW, Holst JJ, Prasad RB, et al

Interestingly, incubation of human skeletal muscle cells with serum obtained from these subjects after the intervention resulted in an increase in PGC-1 expression, AMPK and SIRT1 activity, and mitochondrial biogenesis

Regarding the inflammatory component in neuronal disorders, ALA and DHLA inhibit inflammasomes in neural tissues by decreasing pro-inflammatory mediators, such as interleukin-2 (IL-2), IFN-, and TNF-, increasing anti-inflammatory cytokines such as interleukin-10 (IL-10), and regulating the transcription of nuclear factors Nrf2 and NF-B in physiological processes

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