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Eating disorders Pre-clinical and mechanistic studies We retrieved only a few pre-clinical and mechanistic articles relevant to GLP-1RAs for eating disorders (Supplementary Section 5)

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Peptide synthesis is a time-intensive operation

These CVOT findings are supported by a real-world study performed in over 3 million patients with T2DM from the United States, in which patients treated with SGLT2is did not have a higher risk of any or lower amputation compared with incretins or other glucose-lowering agents [77]