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A Volcano plot of showing DEGs intestine from intestine of DB and GLP-1RA groups, N = 3, B GO enrichment of all overlapping DEGs from intestine of DB and GLP-1RA groups, N = 3, C Heatmap of all DEGs in pyroptosis pathway, N = 3, D Bacterial community structure analysis at phyla level from all groups, N = 6, E , F Relative abundance of Firmicutes ( E ) and Bacteroidetes ( F ), N = 6, G Bacterial community structure analysis at family level, N = 6, H , I , G , Relative abundance of Muribaculaceae ( H ), Lactobacillus ( I ) and Akkermansia ( G ), N = 6