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This suggests that, to maintain weight loss, treatment for obesity should be considered chronic (as in the case of hypertension), rather than as a short course of treatment associated with acute illnesses [9, 55]

Also of concern is the possibility of Stevens-Johnson Syndrome

J Clin Endocrinol Metab, 81: 460-465 Merriam GR, Kletke M, Barsness S, et al

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Directly, many substances in cigarette smoke possess cytotoxic properties that induce oxidative stress, a critical pathway in liver injury and fibrosis [5]