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According to Dr Aravinda, congenital diseases include Immerslund-Grsbeck illness, which causes severe vitamin B12 insufficiency, and genetic intrinsic factor abnormalities which can both lead to severe vitamin B12 deficiency

The question of Can Long COVID Trigger ME/CFS

Its a two-way street in IBD, with the gut microbiome changes potentially causing high homocysteine, but then high homocysteine will increase the inflammation in the gut.[ref] Gastrointestinal production of homocysteine: Gut microbes that produce folate: The amount of folate produced by the gut microbiome is on a similar scale to what we get from food, so it is a significant source of folate for most people

Oxidative stress: implications for the development of diabetic retinopathy and antioxidant therapeutic perspectives

It doesn't override thermodynamics