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Research in animal models has shown sustained reductions in body weight gain and increased fat oxidation over extended treatment periods, with individual results varying considerably based on adherence to diet and exercise protocols alongside peptide use

Multiply that across weeks and your entire protocol is compromised

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As UBS analyst Colin White observed, REDEFINE 4 had been designed at a point when Novo Nordisk believed CagriSema might outperform Zepbound, which made the miss more striking

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