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Limitations of Current Evidence Several significant limitations in the current evidence base warrant acknowledgment: Population Diversity : Most major trials have been conducted in predominantly white, well-resourced populations, potentially limiting generalizability to more diverse demographic groups where obesity prevalence is often highest

What we can say with confidence: retatrutide produces greater absolute weight loss in the timeframes studied

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Population-based black-box optimization for biological sequence design

Participants experienced reductions in waist circumference, improvements in blood pressure, better lipid profiles including lower triglycerides and increased HDL cholesterol, and enhanced glycaemic control

Buteau, J., Roduit, R., Susini, S