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1 The increasing burden of obesity during adolescence is of particular concern because excess weight gained during this critical developmental period frequently persists into adulthood, substantially increasing long-term morbidity and mortality

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Related work showed context-appropriate angiogenesis during muscle/tendon healing, with VEGF-linked markers in vivo (Brcic 2009)

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Common examples of GLP-1 receptor agonists include: Semaglutides(Ozempic and Wegovy) Tirzepatide (Maunjaro and Zepbound) Liraglutide (Victoza and Saxenda) These medications are currently approved for specific medical uses, including: Management of Type 2 diabetes Treatment of certain weight-related medical comorbidities, following clinical guidelines From a physiological perspective, GLP-1 medications support metabolic regulation through several coordinated effects: Increasing insulin secretion in response to food intake Slowing gastric emptying, which prolongs feelings of fullness Reducing glucagon release to help stabilize blood glucose levels Beyond digestion and metabolism, GLP-1 receptors are also found in brain regions involved in reward, motivation, and decision-making

DOI: 10.1038/s41591-022-02026-4 Tolhurst G, Heffron H, Lam YS, et al