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The AACE 2023 consensus statement on obesity pharmacotherapy echoes this position, noting that "escalation within a single mechanism class should be exhausted before combination strategies are considered" [5]

Akkermansia muciniphila , Hungatella hathewayi , Ruthenibacterium lactatiformans and Eisenbergiella tayi have been found in higher proportion in the patients diagnosed with MS while beneficial microbes that produce SCFAs like Faecalibacterium prausnitzii and Blautia sp