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The discovery of semaglutide can be traced back to Novo Nordisk's extensive research on GLP-1 analogs aimed at improving diabetes treatments

Expected Weight Loss Timeline: Weeks to Months During the first month on semaglutide, average weight loss ranges from 2 to 5 pounds, though this varies widely based on individual factors like starting weight, baseline metabolism, and dose escalation schedule

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Therefore, the reduction of foam cells with GLP-1RAs treatment is speculated to inhibit vascular senescence and delay the progression of atherosclerosis

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