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12 mg only if required, not by default the 12 mg arm carried a distinct side-effect profile

The deletion of hexokinase-2, which is upregulated in inflammatory bowel illness, reduces mitochondrial respiration and intestinal cell mortality

O.LejonC.Ekstrand-HammarstromB.AkfurC.AhlinderL.BuchtA.et al (2011)

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Anti-neuroinflammation effects of transcutaneous auricular vagus nerve stimulation against depression-like behaviors via hypothalamic alpha7nAchR/JAK2/STAT3/NF-kappaB pathway in rats exposed to chronic unpredictable mild stress

Nutrients 15(13):3010 Grimm ER, Steinle NI (2011) Genetics of eating behavior: established and emerging concepts