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As new findings emerge, GLP-1 medications are changing how researchers and clinicians think about body weight

JAMA 330 , 21432144 (2023)

[DOI] [PubMed] [Google Scholar] 73.von Loeffelholz C, Birkenfeld AL

Weight loss at 24 weeks (primary endpoint): Weight loss at 48 weeks (secondary endpoint): The weight loss curves had not plateaued at 48 weeks

Artificial intelligence is transforming drug discovery for GLP-1 analogues by rapidly analyzing vast datasets from chemical libraries, preclinical studies, and clinical trials to identify promising molecular candidates

Interestingly, maximal respiration and reserve capacity are both estimated from OCR measurements after injection of FCCP, an uncoupling agent that elevates mitochondria to their maximum electron transport capacity