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Theat least partial [24,97]structural and chemical similarity to physiological bio-molecules can explain the ability of thiol-bound Mercury(II) species to cross biological membranes by using the physiological transport systems of the natural substrates [21] and its ability to undergo chemical modifications operated by the enzymes which process bio-molecules such as those of the soluble thiolome

However, these medications also slow digestion and reduce appetiteleading to significant weight loss in many patients

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BMS has filed extensively on combination regimens with ipilimumab (Yervoy), and some of those combination patents contain matter that post-dates the initial nivolumab disclosures structurally identical to the scenario where a CIP would have been deployed