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Glucagon receptor antagonism for the treatment of type 2 diabetes
Comparator Selection : Many trials use placebo comparisons rather than active comparators, limiting understanding of relative effectiveness compared to existing obesity treatments
By demonstrating protective effects in a ciliopathy model, this study suggests that GLP-1 RAs may confer benefits beyond appetite suppression in patients with genetic obesity syndromes affecting ciliary function, further broadening the mechanistic rationale for targeting this pathway across diverse genetic etiologies of obesity
However, the high development cost of GLP-1 drugs can hamper the global GLP-1 receptor agonist market growth
