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Regarding the incidence rates of major adverse cardiovascular events (MACE), liraglutide was superior to placebo in the LEADER cardiovascular outcomes trial (CVOT)

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31 randomized controlled trials, involving more than 35,000 patients show that tirzepatide 15 mg had the highest efficacy compared with placebo for achieving 15% weight loss, ranking in the top glycemic profile, lipid parameters, and blood pressure