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Elderly patients (75+ years) Considerations: Multiple medications increasing interaction risks, reduced kidney/liver function affecting peptide clearance, fragile vessels increasing injection bruising, cognitive changes potentially affecting protocol adherence, fixed incomes limiting expensive interventions

10.4103/JPBS.JPBS_6_19 35 JungS.WuK.GiovannucciE.SpiegelmanD.WillettW

Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle

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Individual peptide use costs half that but delivers less than half the metabolic outcome due to cofactor and pathway limitations

It boosts glycolysis, activates RORt, and degrades Foxp3 (56, 57)