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Weight gain or obesity Insulin resistance Metabolic syndrome Polycystic ovary syndrome Fatty liver Semaglutide and tirzepatide (GLP-1/GIP agonists) work by mimicking gut hormones that control blood sugar, appetite, and insulin sensitivity

These are the hypothalamus and pituitary glands

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,, This combination is still under investigation in clinical development programs to better understand how simultaneous activation of amylin-related and GLP-1-related pathways influences biological outcomes