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At the highest doses, retatrutide seems to promise more significant weight loss than existing GLP-1s on the market but as dosage increases, so does the risk of side effects, mostly mild-to-moderate gastrointestinal issues, although one case of pancreatitis occurred in a patient on the 12mg dose during the phase II trial

Autism symptom severity was assessed using the Childhood Autism Rating Scale (CARS), a validated behavioral rating instrument [25]

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While intensive glycemic treatment to achieve low HbA1c targets reduced the long-term risk of microvascular complications (retinopathy, nephropathy, and peripheral neuropathy), it has not been shown to significantly reduce the risk of major adverse CV events [24-27]