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DAC = Drug Affinity Complex It's a modification (a reactive maleimido group) attached to the peptide that allows it to bind covalently to albumin the most abundant protein in blood

We next determined if the apparent protective effects of etomoxir were limited to one cell type or to one ER stressor

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N Engl J Med 375:18341844 Lincoff AM, Brown-Frandsen K, Colhoun HM et al (2023) Semaglutide and cardiovascular outcomes in obesity without diabetes

For example, MYC and KRAS overexpression are involved in diverse metabolic changes, including increased glucose uptake and rewiring of GSH biosynthesis [10, 11]

The mixture was centrifuged at 40,000 RPM for 18 hr in a Beckman SW50.1 rotor at 21C