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Accompanied by neurologic symptoms such as leg weakness, numbness, bowel or bladder dysfunction, or saddle anesthesiathese are red flags for cauda equina syndrome or severe nerve compression requiring emergency evaluation

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Likewise, in a meta-analysis conducted by Memon et al.59 that included 17 clinical trials and a total of 1,009 patients, the concomitant use of metformin with probiotics was associated with fewer gastrointestinal adverse effects (OR 0.18, 95% CI 0.09-0.3.8)

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