ocular side effects of glp 1 Research commissioned by AOA and conducted by Talker Research suggests that GLP-1 medications can be associated with rare but serious eye-related effects, and a majority GLP-1 users surveyed weren't aware The Impact of Glucagon-like Peptide-1

Cell 48 , 185191 (1987)

Akkermansia bacteria help maintain gut barrier integrity and promote GLP-1 production

Limitations Not yet FDA-approved (as of 2025)

Health Canada has not yet reviewed or approved Retatrutide for any clinical indication, and approval timelines align with expected FDA decisions in 2026-2027

Metformin : This prescription medication has a long and well-researched history of not only managing insulin resistance and age-related weight gain, but reducing inflammation, improving symptoms of menopause (such as fatigue), and even promoting longevity

Paluch AE, Boyer WR, Franklin BA, Laddu D, Lobelo F, Lee DC, et al