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Week-by-week dosage comparison Weight loss comparison at matched timepoints *Tirzepatide 24 and 48-week figures estimated from SURMOUNT-1 trajectory data, as primary endpoint was 72 weeks

58 Food polyphenols can also induce apoptosis in cancer cells such as breast carcinoma cell line (MCF-7), human laryngeal epithelioma cell line (HEp2), human cervical cancer cell line (HeLa), human hepatoma cell line (HepG2), human hepato-cellular liver carcinoma cell line (HepG2), acute myeloid leukemia cell line (AML)

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Foundational work from the de Keizer laboratory (Baar et al., Cell, 2017) reported that the peptide perturbs the FOXO4-p53 association, leading to p53 nuclear exclusion and apoptosis that appeared preferential to senescent cells in cultured cells and aged mouse models

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