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The dominant impurities present at this include peptides with: Residue deletions Partial deprotections Sequence isomers Charge variants Aggregates Residue deletion peptides, partial deprotections, and sequence isomers usually represent the significant classes of impurities immediately after solid-phase peptide synthesis (SPPS) or the "crude" stage

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FIGURE 3 To further confirm the hypothesis of a regulation of CBS activity by the Akt/GSK3 and/or NF-B pathways, we assessed the impact of inhibitors of these pathway (9-methylstreptimidone, 8-hydroxy verrucarin A, chrysomycin and daunorubicin) on the mRNA levels of CBS , CSE and NAD(P)H quinone oxidoreductase 1 ( NQO1 ), three genes known to be regulated by these pathways (Wang et al., 2014