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Studies by Pickart and colleagues published in 2012-2018 showed that GHK-Cu treatment of cultured human fibroblasts altered expression of several thousand genes, with patterns indicating increased expression of genes involved in tissue repair, antioxidant responses, protein synthesis, and cellular rejuvenation

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Review literature describing these studies frequently frames BPC-157 within broader research on peptide-mediated modulation of vascular signaling, extracellular matrix organization, and nitric oxideassociated cellular responses during injury recovery [2]

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