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AIDS 2005;19:1051-8

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Two downstream consequences are mechanistically central: nicotinamide is preserved for re-entry into the NAD+ salvage pathway (raising intracellular NAD+ availability), and SAM is preserved for other methylation reactions

It acts by mimicking the endogenous hormone ghrelin and binding to the growth hormone secretagogue receptor type 1a (GHS-R1a) in the anterior pituitary gland

For example, aging plasmacytoid dendritic cells (pDCs) exhibit limited production of IFN-I due to impaired IRF7 phosphorylation, resulting in decreased presentation of antigens to T lymphocytes

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