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10.1021/acsnano.1c00498 8 DengY.WangY.JiaF.LiuW.ZhouD.JinQ.et al (2021)

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Naltrexone (TRMP3 variant): A 2019 cell study using CFS/ME cells from 8 different patients showed that Naltrexone restored TRPM3 function.[ref] Keep in mind that this is just a cell study (not a randomized, double-blind, placebo-controlled trial), but it may be worth talking with your doctor about this study, especially if you carry a TRPM3 variant linked to CFS