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The review documented the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, inhibition of food intake, natriuresis and diuresis, and modulation of -cell proliferation as key pancreatic and gastrointestinal actions

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Our findings provide important evidence supporting clinical reports of weight gain following incretin agonist discontinuation in patients 38

PMID 24464856

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By keeping more of these chemicals active, tesofensine suppresses appetite through 1 adrenoceptor and dopamine D1 pathways and can silence GABAergic hypothalamic neurons involved in hunger and satiety