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Others experience significant GI discomfort

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The lower rate of non-CV deaths was because of lower infectious deaths, in particular COVID-19related deaths, suggesting that semaglutide has a favorable outcome in terms of mortality across a broad population of patients with CV disease and obesity (88)

This can lead to feelings of fullness, but it may also result in discomfort and increased gastric pressure, which can trigger diarrhea

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These modifications reduce affinity for IGF-binding proteins