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However, it also increases commoditization risk as generic versions of these drugs become available

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This modification serves to open the chromatin structure of the adiponectin gene, facilitate the binding of transcription factors, and thereby activating the expression of the adiponectin gene

insulin resistance abrogates this suppression, increasing FMO3 expression and plasma TMAO, positioning TMAO as a liver insulin resistance marker (151)

doi: 10.1210/jcem-72-1-51 89 FrystykJBrickDJGerweckAVUtzALMillerKK