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The moment a patient hits a dose that causes troublesome nausea or loss of appetite beyond whats manageable, Nooms clinician-designed protocol holds at that dose longer, or even dials back to the prior dose until symptoms subside

This may include: Sustainable weight loss requires consistency and guidance

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The STEP-1 data show that nausea rates peak during the first four weeks and decline substantially by week 20, even as patients continue escalating toward 2.4 mg [1]

However, its half-life in the bloodstream is remarkably short, around 15 minutes, due to rapid degradation by aminopeptidase enzymes