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In very high doses there is a potential for nausea and pain at the injection site

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Steric hindrance from the increased side-chain volume of E14 Cagri and R17 Cagri promotes a shift of the -helix of Cagri away from ECL2 and a slight expansion of the peptide binding pocket at the extracellular side of the CTR TM domain, relative to those observed with rAmy/San385-bound AMYR complexes

CMS has concluded that these programs were funded entirely without Medicaid funds prior to their approval, and the additional federal funds that they received does not render these programs as integral components of section 1115 demonstration programs. CMS now frowns on the notion that the federal government should: (i) share in the costs of funding these state programs

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