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These reactions are typically mild and transient

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CoA is a cofactor in more than 70 enzymatic pathways including: Amino acid catabolism Acetylcholine synthesis Carbohydrate metabolism Fatty acid oxidation Heme synthesis Pyruvate degradation Phase II detox acetylation CoA is also involved in the initial steps of cholesterol synthesis and all the downstream metabolites of cholesterol including steroids, Vitamin D, and bile acids