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Therefore, to further assess the effect of metformin on both rectal cancer and normal, non-cancer rectal tissue, the protein secretome of treatment nave rectal tumour biopsies and non-cancer biopsies was assessed following metformin treatment

Curcumin administration has been associated with beneficial changes in gut microbiota composition, leading to improved intestinal barrier function and reduced endotoxin levels that may contribute to liver inflammation through toll-like receptor (TLR) pathways

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For instance, inflammatory cells release chemical mediators of inflammation, particularly ROS