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Abbreviations ICU: Intensive care unit CoA: Coenzyme A AKI: Acute kidney injury PN: Parental nutrition HIV: Human immunodeficiency virus CRP: C-reactive protein IL-6: Interleukin-6 TNF-: Tumor necrosis factor- SOFA: Sequential organ failure assessment score FBG: Fasting blood glucose Na: Sodium K: Potassium Ca: Calcium Mg: Magnesium AST: Aspartate aminotransferase ALT: Alanine aminotransferase Alb: Albumin WBC: White blood cells Hb: Hemoglobin PLT: Platelet BUN: Blood urea nitrogen Cr: Creatinine INR: International normalized ratio SPSS: Statistical Package for the Social Sciences ANCOVA: Analysis of covariance CAD: Coronary artery disease PTH: Parathyroid hormone TBI: Traumatic brain injury IV: Intravenous NAFLD: Non-alcoholic fatty liver disease NASH: Nonalcoholic steatohepatitis References McClave SA, Taylor BE, Martindale RG, Warren MM, Johnson DR, Braunschweig C, et al

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Metformin, proton pump inhibitors, and H2 blockers are common medications linked to vitamin B12 deficiency also [1,2]

For the latter reason, it is included in the RUCAM scoring system, as the rate of liver injury resolution strengthens or weakens the case for causality

Initial research landed it in anti-aging medicine, with trials seeing shifts in indicators of aging and immune function