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mTORC1 activation follows: Raptor Ser-792 dephosphorylation, S6K1 Thr-389 phosphorylation (1.6-2.0), 4E-BP1 Thr-37/46 phosphorylation (1.4-1.8), eIF4E liberation, and eIF4B Ser-422 phosphorylation
The lowest quartile of patients had GGT values between 1 U/L and 11 U/L in men and 1 U/L and 6 U/L in women, and the highest quartile included men with GGT values from 25 U/L to 99 U/L and women with GGT values from 14 U/L to 88 U/L
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In line with these observations, induced degradation of endogenously Halo-tagged TRF1 reduced telomere association of overexpressed TIN2 and POT1 but not TRF2, which is proposed to form a separate subcomplex with RAP1 47
