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Fang and Bohr 2017

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Comparison with the cDNA sequences of other -defensins revealed 45-52% similarity to the bovine, caprine, and porcine homologs, respectively

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We then discuss the possible aetiology of ALS and illustrate how strong risk factors including environmental toxins such as BMAA and heavy metals can functionally behave to promote protein aggregation and disturb copper metabolism that likely drives this vicious cycle in sporadic ALS