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MHRA advises restricted use Loperamide for diarrhoea management when appropriate, but should be avoided if blood in stools, fever, or suspected inflammatory/infectious diarrhoea Laxatives for constipation, with macrogol (polyethylene glycol) preparations typically first-line in UK practice, alongside optimising dietary fibre and hydration Dose adjustment strategies include temporarily maintaining a lower dose if gastrointestinal side effects are problematic, allowing additional time for adaptation before escalation
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Patients may appreciate the user-friendly and discreet option offered by these brands compared to other insulin treatments
For example, people who took semaglutide could walk about 42 meters further than those on the placebo in a six-minute walking test
