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Rapamycin has been extensively studied for immunomodulatory effects across autoimmune diseases

doi: 10.1371/journal.pone.0161158

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Previous studies have confirmed that ROS-induced histone deacetylation can suppress the expression of anti-apoptotic genes, promoting apoptosis and exhaustion in T cells [85, 86]

Four hundred and thirty (88%) of these patients have conditions for which the drug is a proven benefit , so the increased frequency of injections accounts for most of the observed excess

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