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A systematic review and meta-analysis of the incidence of pancreatitis following the use of immune checkpoint inhibitors in patients with advanced cancer found that the incidence of pancreatitis was significantly higher following the use of immune checkpoint inhibitors, with a grade 2 pancreatitis of 1.9% (150/7,702) ( Azathioprine, a prodrug of 6-mercaptopurine, is converted into Mercaptopurine by glutathione S-transferase in the liver

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This shift reflects growing recognition of GLP-1 agonists as effective weight loss tools independent of diabetes status