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References Leslie SW, Siref LE, Soon-Sutton TL, Khan MAB
Cellular senescence: when bad things happen to good cells
In the nucleus, HMGB1 can interact with DNA and histones to maintain chromosome structure and function, while, in the cytoplasm, HMGB1 can combine with Beclin 1 protein to promote autophagy
The two are commonly referenced in literature with regards to tissue and cell research, both are easy to come by in terms of synthesized form for in vitro experiments, and both are often compared side-by-side with regards to structure and mechanism