Because we just dont know yet exactly what the long-term outcomes are for people who become pregnant while taking these medications. One early study suggested that using GLP-1 agonists during the first trimester didnt harm fetal development
D.SchraderA
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In ovarian cancer cell lines SKOV-3 and OVCAR-3, Ex-4 induces apoptosis by modulating NF-B downstream targets, including matrix metalloproteinase-9 (MMP-9), intercellular adhesion molecule-1(ICAM-1), BAX, Bcl-2, and cyclin D [68]
In PCOS patients the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism than metformin alone