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Fumaric acid accumulation also inhibits the activity of adenylosuccinate lyase (ADSL) in the purine de novo synthesis pathway, resulting in an increase in succinylaminoimidazolecarboxamide ribose (SAICAR) and adenosine succinate, which can cause damage to the central nervous system [84]

When vomiting or diarrhea occurs, you lose fluids

Eating smaller, protein-rich meals and avoiding greasy or overly sweet foods can minimize digestive discomfort

Clinical distinction between medication-induced effects and weight-loss-associated changes remains challenging

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