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AhR ligands include several indole derivatives, such as indoleacetic acid (IAA), indole-3-ethanol, and indole acrylic acid (IA), produced by tryptophan (Trp) metabolism (Gu et al., 2021

Although migraine duration varies from patient to patient, a typical attack lasts for several hours, and sometimes persists for up to several (e.g

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Sporadic dosing or frequent gaps reset these adaptive mechanisms, forcing your body to re-establish appetite suppression each time you resume, which is physiologically inefficient and psychologically harder than maintaining steady weekly dosing from the outset