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In August 2025, a review found that flavonoids, which contribute to bitter flavors in, say, citrus or hops, can stimulate GLP-1 release, too

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Injection frequency depends on the peptide's half-life and mechanism

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For both therapeutic classes, this increased risk of gallbladder or biliary diseases has been thought to be driven by the inhibition of the secretion of cholecystokinin by GLP-1, leading to impaired gallbladder motility and contractility [64, 65]